RHINOS follow-up study (RHINUP) on HIV drug resistance
Our doctoral student, Anna Baumann, and her team were able to start recruitment for this clinical study on HIV drug resistance. HIV-infected adults that previously participated in the RHINOS study and were either treatment experienced and diagnosed with virological failure, or treatment-naïve and diagnosed with pretreatment HIV drug resistance mutations, are invited to participate.
Our second doctoral student, Dana Weissberg, who is looking at opportunistic infections within a large IDI cohort has completed the process of data cleaning. Frank Mubiro, statistician at IDI, is now helping her analyze the data.
In addition to the recently completed SOUTH study we are currently enrolling patients into this study in which serum concentrations of tuberculosis medication are measured at multiple time points within 24 hours of ingestion. The new time points will enable us to clearly define the area under the concentration curve over 6 hours (AUC0-6h) in a population of HIV/TB co-infected adults.
Urinary tract infections (UTI) are among the most frequent infectious diseases. Due to a global increase in bacteria resistant to broad-spectrum antibiotics, empirical antibiotic therapy will be evermore challenging.
The aim of this project is to identify the bacterial species and resistance patterns found in urine specimens collected from women with UTI in Kampala. In order to achieve this, women above the age of 18 years with confirmed UTI irrespectively of their HIV-status will be included. Cultures and resistance testing will be performed on-site in collected urine samples. If successful, we plan to roll out our surveillance project to other centers in the region.