Sexually transmitted infections (STIs) are among the most common infectious diseases. The World Health Organization (WHO) estimates 340 million new cases of STIs occur annually, with young adults at highest risk. Syphilis is an important public health problem in Uganda and other sub-Saharan Aftrican countries. The infection is of particular concern during pregnancy because it can be transmitted to the fetus, and the burden of this is estimated at 600,000 disability adjusted life years in Uganda alone. The aim of this project is to improve diagnosis and treatment of three key sexually transmitted infections (syphilis, gonorrhea, and chlamydia) in Kampala in a sustainable manner, using innovative laboratory testing approaches. If successful, the project will be well placed for national funding or implementation partner funding as it is aligned with country priorities.