Cohort profile of a study on outcomes related to tuberculosis and antiretroviral drug concentrations in Uganda: design, methods and patient characteristics of the SOUTH study.
Abstract PURPOSE: Tuberculosis (TB) is a leading cause of death among people living with HIV in sub-Saharan Africa. Several factors influence the efficacy of TB treatment by leading to suboptimal drug concentrations and subsequently affecting...
Anti-TB drug concentrations and drug-associated toxicities among TB/HIV-coinfected patients
Abstract Background: Toxicities due to anti-TB treatment frequently occur among TB/HIV-coinfected patients. Objectives: To determine the association between anti-TB drug concentrations and the occurrence of hepato- toxicity and peripheral neuropathy among TB/HIV-coinfected patients. Methods:...
Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis
Abstract Background: This cross-sectional study took place in the integrated tuberculosis (TB) clinic of a large outpatient clinic for HIV-infected patients in Kampala, Uganda. The purpose of this study was to describe the proportion...
Challenges in achieving a target international normalized ratio for deep vein thrombosis among HIV-infected patients with tuberculosis: a case series
Abstract Background: Tuberculosis (TB) and HIV are among the risk factors for deep vein thrombosis (DVT). There are several challenges in the management of DVT patients with TB-HIV co-infection including drug-drug interactions and non-adherence...
Low prevalence of pre-treatment HIV-1 drug resistance in Ugandan adults
Authors: Amrei von Braun (1,2), Christine Sekaggya (1), Alexandra Scherrer (2,3), Brian Magambo (4), Deogratius Ssemwanga (4), Pontiano Kaleebu (4), Huldrych Günthard (2,3), Andrew Kambugu (1), Jan Fehr (2), Barbara Castelnuovo (1) Affiliations: Infectious...
High rates of multi class drug resistance in HIV-1 infected individuals monitored with CD4 count in Uganda
Authors: Amrei von Braun (1,2), Alexandra Scherrer (2,3), Christine Sekaggya (1), Joseph Kirangwa (4), Deogratius Ssemwanga (4), Pontiano Kaleebu (4), Huldrych Günthard (2,3), Andrew Kambugu (1), Barbara Castelnuovo (1), Jan Fehr (2) Affiliations: Infectious...
Low rifampicin and isoniazid concentrations are associated with delayed sputum conversion in HIV positive patients co-infected with tuberculosis in Uganda.
Authors: Christine Sekaggya-Wiltshire(1), Bruno Ledergerber(2), Amrei von Braun(1,2), Mohammed Lamorde(1), Allan Buzibye(1), Nadia Eberhard(1,2), Alexandra Scherrer (2), Rita Nakijoba(1), Daniel Muller(3), Lars Henning(2), Ursula Gutteck (3), Natascia Corti(4), Joseph Musaazi(1), Moses Kamya(5), Barbara Castelnuovo(1),...
“If at first you don’t succeed, try again”: Looking beyond Initial Results of a Failed Tuberculosis Diagnosis
Abstract: We report the outcome of investigations conducted in 73 human immunodeficiency virus (HIV) infected Ugandan adults presumed to have pulmonary tuberculosis (PTB). Following initial investigations, 32 of 73 patients were diagnosed with PTB....
Low isoniazid and rifampicin concentrations in TB/HIV co-infected patients in Uganda
Authors: Sekaggya C (1), Lamorde M (1), Scherrer A.U (2), Musaazi J (1), Corti N (2), Buzibye A (1), Nakijoba R (1), Nalwanga D (1), Henning L (2), von Braun A (1), Okware S...
Association of anti-tuberculosis drug levels serum concentrations with drug-related adverse events in TB/HIV co-infected patients in Uganda
Authors: C. Sekaggya (1), A. von Braun (1), B. Ledergerber (2), A. Buzibye (1), A. Scherrer (2), M. Lamorde M, D. Nalwanga (1), L. Henning (2), D. Muller (2),U. Gutteck (2), B. Castelnuovo (1),...